RASGRP1 O95267

RAS鸟苷酸释放蛋白1 (钙和DAG调节的鸟嘌呤核苷酸交换因子II) (CalDAG-GEFII) (Ras鸟苷酸释放蛋白)

功能描述

作为一种钙和二酰甘油(DAG)调节的核苷酸交换因子发挥作用，通过将结合的GDP交换为GTP特异性激活Ras (PubMed:15899849, PubMed:23908768, PubMed:27776107, PubMed:29155103)。激活Erk/MAP激酶级联反应 (PubMed:15899849)。通过将T淋巴细胞/B淋巴细胞抗原受体偶联至Ras，调节T细胞/B细胞的发育、稳态和分化 (PubMed:10807788, PubMed:12839994, PubMed:27776107, PubMed:29155103)。通过激活Ras介导的ERK和JNK通路，调节NK细胞的细胞毒性和ITAM依赖性细胞因子产生 (PubMed:19933860)。在肥大细胞脱颗粒和细胞因子分泌中发挥作用，调节FcERI诱发的过敏反应。也可能在其他细胞类型的分化中发挥作用 (PubMed:12845332)。 {ECO:0000250|UniProtKB:Q9Z1S3, ECO:0000269|PubMed:10807788, ECO:0000269|PubMed:12782630, ECO:0000269|PubMed:12839994, ECO:0000269|PubMed:12845332, ECO:0000269|PubMed:15060167, ECO:0000269|PubMed:15184873, ECO:0000269|PubMed:15899849, ECO:0000269|PubMed:19933860, ECO:0000269|PubMed:23908768, ECO:0000269|PubMed:27776107, ECO:0000269|PubMed:29155103}。

组织特异性

Expressed in brain with higher expression in cerebellum, cerebral cortex and amygdala. Expressed in the hematopoietic system. Expressed in T-cells (at protein level). Expressed in NK cells (at protein level) (PubMed:19933860).

亚细胞定位

Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Found both in the cytosol and associated with membranes. Relocalization to the cell membrane upon activation is F-actin-dependent. Translocates to the Golgi in response to phorbol ester or nerve growth factor. Localizes to somata and dendrites but not to axons of hippocampal pyramidal cells (By similarity).