RASGRF2 O14827

Ras特异性鸟苷酸释放因子2 (Ras-GRF2) (Ras鸟苷酸交换因子2)

功能描述

作为一种钙调节的核苷酸交换因子发挥作用，通过将结合的GDP交换为GTP来激活Ras和RAC1。基于不同的异戊二烯化类型，在体内优先激活HRAS而非RRAS。通过参与长时程增强的诱导，在突触可塑性中发挥作用。 {ECO:0000269|PubMed:15128856}。

组织特异性

Widely expressed with higher expression in brain, followed by heart, lung, pancreas and kidney. Detected in placenta. Expressed in brain and lung (at protein level).

亚细胞定位

Cytoplasm. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Translocates to membranes when activated. Found both at cell periphery and along the axon of neurons (By similarity).