RAPGEF4 Q8WZA2

Rap鸟苷酸交换因子4 (被cAMP直接激活的交换因子2) (被cAMP直接激活的交换蛋白2) (EPAC 2) (cAMP调节的鸟苷酸交换因子II) (cAMP-GEFII)

蛋白质信息 (UniProt)

Rap鸟苷酸交换因子4 (被cAMP直接激活的交换因子2) (被cAMP直接激活的交换蛋白2) (EPAC 2) (cAMP调节的鸟苷酸交换因子II) (cAMP-GEFII)

Q8WZA2

功能描述

RAP1A、RAP1B和RAP2A小GTPases的鸟嘌呤核苷酸交换因子(GEF)，通过结合cAMP激活。似乎不激活RAB3A。通过与RIMS2相互作用参与cAMP依赖性、PKA非依赖性的胞吐作用(根据相似性)。{ECO:0000250, ECO:0000269|PubMed:10777494, ECO:0000269|PubMed:9856955}。

组织特异性

Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels.

亚细胞定位

Cytoplasm. Membrane

关键词

Alternative promoter usage Alternative splicing cAMP cAMP-binding Cytoplasm Exocytosis Guanine-nucleotide releasing factor Membrane Nucleotide-binding Proteomics identification

外部链接

UniProt: Q8WZA2

NCBI Gene

GeneCards