RAET1L Q5VY80

UL16结合蛋白6 (视黄酸早期转录1L蛋白)

功能描述

结合并激活KLRK1/NKG2D受体，介导自然杀伤细胞细胞毒性。 {ECO:0000269|PubMed:19658097, ECO:0000269|PubMed:28559451}.

组织特异性

Widely expressed (PubMed:11827464). Expressed in trachea (PubMed:19658097). Constitutively expressed in peripheral blood mononuclear cells, including B-cells and natural killer cells, as well as CD4+ and CD8+ T-cells and monocytes. Tends to be up-regulated in various lymphoid malignancies, including chronic lymphocytic leukemia (PubMed:28559451).

亚细胞定位

Cell membrane