RAET1E Q8TD07

视黄酸早期转录本1E (淋巴细胞效应子毒性激活配体) (NKG2D配体4) (N2DL-4) (NKG2DL4) (RAE-1样转录本4) (UL16结合蛋白4)

功能描述

结合并激活KLRK1/NKG2D受体，介导自然杀伤细胞细胞毒性。 {ECO:0000269|PubMed:15240696, ECO:0000269|PubMed:18544572}.

组织特异性

Predominantly expressed in the skin, but also expressed in testis and trachea. Up-regulated in tumor cells of different origins. Expression progressively decreased after treatment of tumor cells with retinoic acid.

亚细胞定位

Membrane