RAB6C Q9H0N0

Ras相关蛋白Rab-6C (EC 3.6.5.2) (Rab6样蛋白WTH3)

功能描述

小GTP酶Rab是细胞内膜运输的关键调节因子，从运输小泡的形成到其与膜融合。Rab在非活性GDP结合形式和活性GTP结合形式之间循环，活性形式能够招募不同组的下游效应因子，直接负责小泡的形成、运动、系留和融合 (By similarity)。RAB6C可能参与中心体复制和细胞周期进程的调节。 {ECO:0000250|UniProtKB:P20340, ECO:0000269|PubMed:17426708, ECO:0000269|PubMed:18992151, ECO:0000269|PubMed:20064528}。

组织特异性

Highest levels are found in fetal and adult brain, prostate, testis and spinal cord. Undetectable expression in adrenal gland, skeletal muscle, bone marrow, fetal, and adult liver, heart, salivary gland, and trachea. Detected in the HEK293, HEK293T, LNCaP, MCF-7, T-47D and EVSA-T cell lines (at protein level).

亚细胞定位

Nucleus