RAB27A P51159

Ras相关蛋白Rab-27A (Rab-27) (EC 3.6.5.2) (GTP结合蛋白Ram)

蛋白质信息 (UniProt)

Ras相关蛋白Rab-27A (Rab-27) (EC 3.6.5.2) (GTP结合蛋白Ram)

P51159

功能描述

小GTPases Rab是细胞内膜运输的关键调节因子，从运输囊泡的形成到其与膜融合。Rabs在非活性GDP结合形式和活性GTP结合形式之间循环，后者能够招募不同组的下游效应因子，直接负责囊泡的形成、运动、系留和融合 (PubMed:30771381)。RAB27A调节晚期内吞途径的稳态，包括内体定位、成熟和分泌 (PubMed:30771381)。在淋巴细胞细胞毒性颗粒胞吐中发挥作用。为免疫突触处的颗粒成熟以及颗粒停靠和启动所必需 (PubMed:18812475)。 {ECO:0000269|PubMed:18812475, ECO:0000269|PubMed:30771381}。

组织特异性

Found in all the examined tissues except in brain. Low expression was found in thymus, kidney, muscle and placenta. Detected in melanocytes, and in most tumor cell lines examined. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells.

亚细胞定位

Membrane

关键词

3D-structure Acetylation Alternative splicing Direct protein sequencing Disease variant Disulfide bond Endosome Exocytosis GTP-binding Hydrolase

外部链接

UniProt: P51159

NCBI Gene

GeneCards