受体型酪氨酸蛋白磷酸酶 R (R-PTP-R) (EC 3.1.3.48) (Ch-1PTPase) (NC-PTPCOM1) (蛋白酪氨酸磷酸酶 PCPTP1)
受体型酪氨酸蛋白磷酸酶 R (R-PTP-R) (EC 3.1.3.48) (Ch-1PTPase) (NC-PTPCOM1) (蛋白酪氨酸磷酸酶 PCPTP1)
Q15256功能描述
将丝裂原活化蛋白激酶(MAPKs)如MAPK1、MAPK3和MAPK14以非活性形式隔离在细胞质中。MAPKs结合去磷酸化的激酶相互作用基序，蛋白激酶A复合物对该基序的磷酸化释放MAPKs以进行激活并易位至细胞核(By similarity)。 {ECO:0000250}。
组织特异性
Detected in cerebrospinal fluid (at protein level) (PubMed:25326458). Expressed in brain, placenta, small intestine, stomach, uterus and weakly in the prostate. Isoform alpha has been observed only in the brain. Isoform gamma is expressed in brain, placenta and uterus. Isoform delta is expressed in brain, kidney, placenta, prostate, small intestine and uterus.
亚细胞定位
Secreted
关键词