前列腺素E合酶2 (EC 5.3.99.3) (膜相关前列腺素E合酶-2) (mPGE合酶-2) (微粒体前列腺素E合酶2) (mPGES-2) (前列腺素-H(2) E-异构酶) [切割为：前列腺素E合酶2截短形式]
前列腺素E合酶2 (EC 5.3.99.3) (膜相关前列腺素E合酶-2) (mPGE合酶-2) (微粒体前列腺素E合酶2) (mPGES-2) (前列腺素-H(2) E-异构酶) [切割为：前列腺素E合酶2截短形式]
Q9H7Z7功能描述
异构酶，催化PGH2转化为更稳定的前列腺素E2 (PGE2)（体外）(PubMed:12804604, PubMed:17585783, PubMed:18198127)。PTGES2的生物学功能和GSH依赖特性仍有争议 (PubMed:17585783, PubMed:18198127)。在体内，PTGES2可能与GSH和血红素形成复合物，不参与PGE2合成，而是催化前列腺素E2 H2 (PGH2) 降解为12(S)-羟基-5(Z),8(E),10(E)-十七碳三烯酸 (HHT) 和丙二醛 (MDA)（根据相似性）(PubMed:17585783)。 {ECO:0000250|UniProtKB:Q9N0A4, ECO:0000269|PubMed:12804604, ECO:0000269|PubMed:17585783, ECO:0000269|PubMed:18198127}。
组织特异性
Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and trachea, but not in the thymus or lung. Overexpressed in colorectal cancer.
亚细胞定位
Golgi apparatus membrane
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