前列腺素-H2 D-异构酶 (EC 5.3.99.2) (Beta-痕量蛋白) (脑蛋白-28) (谷胱甘肽非依赖性PGD合酶) (脂质运载蛋白型前列腺素-D合酶) (L-PGDS) (前列腺素-D2合酶) (PGD2合酶) (PGDS) (PGDS2)
前列腺素-H2 D-异构酶 (EC 5.3.99.2) (Beta-痕量蛋白) (脑蛋白-28) (谷胱甘肽非依赖性PGD合酶) (脂质运载蛋白型前列腺素-D合酶) (L-PGDS) (前列腺素-D2合酶) (PGD2合酶) (PGDS) (PGDS2)
P41222功能描述
催化PGH2转化为PGD2，PGD2是一种参与平滑肌收缩/舒张的前列腺素，也是血小板聚集的有效抑制剂 (PubMed:20667974)。参与多种CNS功能，如镇静、NREM睡眠和PGE2诱导的异常性疼痛，并可能在少突胶质细胞中具有抗凋亡作用。结合小的非底物亲脂性分子，包括胆绿素、胆红素、视黄醛、视黄酸和甲状腺激素，可能作为有害疏水分子的清除剂以及分泌型类视黄醇和甲状腺激素转运体。可能参与血脑、血视网膜、血房水和血睾屏障的发育和维持。它很可能在CNS和男性生殖系统的成熟及维持中发挥重要作用 (PubMed:20667974, PubMed:9475419)。参与PLA2G3依赖性的肥大细胞成熟。PLA2G3由未成熟肥大细胞分泌，作用于附近的成纤维细胞，在PTDGS上游合成PGD2，进而通过PTGDR促进肥大细胞成熟和脱颗粒 (By similarity)。 {ECO:0000250|UniProtKB:O09114, ECO:0000269|PubMed:20667974, ECO:0000269|PubMed:9475419}。
组织特异性
Abundant in the brain and CNS, where it is expressed in tissues of the blood-brain barrier and secreted into the cerebro-spinal fluid. Abundantly expressed in the heart. In the male reproductive system, it is expressed in the testis, epididymis and prostate, and is secreted into the seminal fluid. Expressed in the eye and secreted into the aqueous humor. Lower levels detected in various tissue fluids such as serum, normal urine, ascitic fluid and tear fluid. Also found in a number of other organs including ovary, fimbriae of the fallopian tubes, kidney, leukocytes.
亚细胞定位
Rough endoplasmic reticulum
关键词