PTBP3 O95758

多聚嘧啶 tract-binding protein 3 (分化调节因子1) (Rod1)

蛋白质信息 (UniProt)

多聚嘧啶 tract-binding protein 3 (分化调节因子1) (Rod1)

O95758

功能描述

RNA结合蛋白，介导pre-mRNA选择性剪接调控。在细胞增殖、分化和迁移的调控中发挥作用。EPO依赖性红细胞生成的正调节因子。通过抑制组织特异性外显子参与细胞分化调控。促进FAS外显子6跳跃。结合RNA，优先结合poly(G)和poly(U)。 {ECO:0000269|PubMed:10207106, ECO:0000269|PubMed:18335065, ECO:0000269|PubMed:19441079, ECO:0000269|PubMed:20937273}。

组织特异性

Expressed in several hematopoietic cell lines examined.

关键词

Acetylation Alternative splicing Differentiation Erythrocyte maturation Isopeptide bond mRNA processing mRNA splicing Phosphoprotein Proteomics identification Reference proteome

外部链接

UniProt: O95758

NCBI Gene

GeneCards