多聚嘧啶区结合蛋白2 (神经多聚嘧啶区结合蛋白) (PTB神经富集同源蛋白) (PTB样蛋白)
多聚嘧啶区结合蛋白2 (神经多聚嘧啶区结合蛋白) (PTB神经富集同源蛋白) (PTB样蛋白)
Q9UKA9功能描述
RNA结合蛋白，结合内含子多聚嘧啶区并介导外显子剪接的负调控。可能以组织特异性方式拮抗NOVA1激活外显子选择的能力。除了在前体mRNA剪接中的功能外，还在翻译调控中发挥作用。 {ECO:0000250|UniProtKB:Q91Z31, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:12667457}.; FUNCTION: [Isoform 5]: 对RNA的亲和力降低。 {ECO:0000269|PubMed:12213192}.
组织特异性
Mainly expressed in brain although also detected in other tissues like heart and skeletal muscle. Isoform 1 and isoform 2 are specifically expressed in neuronal tissues. Isoform 3 and isoform 4 are expressed in non-neuronal tissues. Isoform 5 and isoform 6 are truncated forms expressed in non-neuronal tissues.
亚细胞定位
Nucleus
关键词