PSRC1 Q6PGN9

富含脯氨酸/丝氨酸卷曲螺旋蛋白1

功能描述

有丝分裂的正常进程所必需。染色体在中期板的正常会聚以及后期染色体分离的正常速率所必需。在有丝分裂纺锤体动力学的调节中发挥作用。增加中期纺锤体上微管的周转速率，并有助于在姐妹动粒之间产生正常张力。将KIF2A和ANKRD53募集到有丝分裂纺锤体和纺锤体极。可能参与p53/TP53调节的生长抑制。 {ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:19738423, ECO:0000269|PubMed:26820536}。

组织特异性

Widely expressed in adult and fetal tissues, with highest expression in the adult brain and fetal thymus. Not detected in adult skeletal muscle.

亚细胞定位

Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Detected at the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase.