PC4和SFRS1相互作用蛋白 (CLL相关抗原KW-7) (致密细斑点70 kDa蛋白) (DFS 70) (晶状体上皮源性生长因子) (转录共激活因子p75/p52)
PC4和SFRS1相互作用蛋白 (CLL相关抗原KW-7) (致密细斑点70 kDa蛋白) (DFS 70) (晶状体上皮源性生长因子) (转录共激活因子p75/p52)
O75475功能描述
参与神经上皮干细胞分化和神经发生的转录共激活因子。特别参与晶状体上皮细胞基因调控和应激反应。可能在晶状体上皮细胞向纤维细胞终末分化中发挥重要作用。可能在应激诱导的凋亡过程中发挥保护作用。Isoform 2 是一种更普遍且更强的转录共激活因子。Isoform 2 也可能作为适配体协调前体mRNA剪接。慢病毒整合的细胞辅因子。 {ECO:0000269|PubMed:15642333}。
组织特异性
Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions.
亚细胞定位
Nucleus
关键词