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PRUNE2 Q8WUY3

蛋白修剪同源物2(C末端区域含BNIP2基序分子1)

蛋白质信息 (UniProt)

蛋白修剪同源物2(C末端区域含BNIP2基序分子1)

Q8WUY3

功能描述

可能在调节肿瘤细胞的分化、存活和侵袭性方面发挥重要作用。 {ECO:0000269|PubMed:16288218}。

组织特异性

A high level of expression seen in the nervous system (brain, cerebellum and spinal cord) as well as adrenal gland. Expressed at high levels in noneuroblastoma, rhabdomyosarcoma, melanoma and some osteosarcoma cell lines, whereas at only low levels in cancer cell lines of liver, breast, thyroid and colon. Expression is significantly higher in favorable tumors than aggressive ones.

亚细胞定位

Cytoplasm

关键词

Acetylation Alternative splicing Apoptosis Cytoplasm Manganese Metal-binding Proteomics identification Reference proteome