外切聚磷酸酶 PRUNE1 (EC 3.6.1.1) (果蝇相关表达序列17) (DRES-17) (DRES17) (HTcD37) (蛋白质prune同源物1) (hPrune)
外切聚磷酸酶 PRUNE1 (EC 3.6.1.1) (果蝇相关表达序列17) (DRES-17) (DRES17) (HTcD37) (蛋白质prune同源物1) (hPrune)
Q86TP1功能描述
磷酸二酯酶 (PDE)，作为底物，对cAMP的活性高于cGMP。在细胞增殖、迁移和分化中发挥作用，并作为NME1的负调节因子。在神经发生的调节中发挥作用 (PubMed:28334956)。参与微管聚合的调节 (PubMed:28334956)。 {ECO:0000269|PubMed:10602478, ECO:0000269|PubMed:11687967, ECO:0000269|PubMed:14998490, ECO:0000269|PubMed:16428445, ECO:0000269|PubMed:17906697, ECO:0000269|PubMed:28334956}。
组织特异性
Ubiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas.
亚细胞定位
Cytoplasm. Nucleus. Cell junction, focal adhesion. Note=In some transfected cells a nuclear staining is also observed.
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