PRR5 P85299

富含脯氨酸蛋白 5 (与Rictor共观察蛋白-1) (Protor-1)

功能描述

mTORC2的相关亚基，mTORC2响应激素信号调节细胞生长和存活 (PubMed:17461779, PubMed:17599906, PubMed:29424687)。mTORC2被生长因子激活，但与mTORC1相反，似乎对营养不敏感 (PubMed:17461779, PubMed:17599906, PubMed:29424687)。mTORC2似乎在Rho GTPases上游发挥作用以调节肌动蛋白细胞骨架，可能是通过激活一种或多种Rho型鸟嘌呤核苷酸交换因子 (PubMed:17461779, PubMed:17599906, PubMed:29424687)。PRR5在调节PDGFRB表达和调节血小板源性生长因子信号传导中起重要作用 (PubMed:17599906)。可能在乳腺癌中作为肿瘤抑制因子发挥作用 (PubMed:15718101)。 {ECO:0000269|PubMed:15718101, ECO:0000269|PubMed:17461779, ECO:0000269|PubMed:17599906, ECO:0000269|PubMed:29424687}。

组织特异性

Most abundant in kidney and liver. Also highly expressed in brain, spleen, testis and placenta. Overexpressed in several colorectal tumors.