PROM1 O43490

Prominin-1 (抗原 AC133) (Prominin样蛋白 1) (CD抗原 CD133)

功能描述

可能在细胞分化、增殖和凋亡中发挥作用 (PubMed:24556617)。在含胆固醇的质膜微区中结合胆固醇，并可能在上皮细胞顶端质膜的组织中发挥作用。在视网膜发育早期，作为盘形态发生的关健调节因子。参与MAPK和Akt信号通路的调节。在神经母细胞瘤细胞中，以依赖RET的方式抑制细胞分化，如神经突生长 (PubMed:20818439)。 {ECO:0000269|PubMed:20818439, ECO:0000269|PubMed:24556617}。

组织特异性

Isoform 1 is selectively expressed on CD34 hematopoietic stem and progenitor cells in adult and fetal bone marrow, fetal liver, cord blood and adult peripheral blood. Isoform 1 is not detected on other blood cells. Isoform 1 is also expressed in a number of non-lymphoid tissues including retina, pancreas, placenta, kidney, liver, lung, brain and heart. Found in saliva within small membrane particles. Isoform 2 is predominantly expressed in fetal liver, skeletal muscle, kidney, and heart as well as adult pancreas, kidney, liver, lung, and placenta. Isoform 2 is highly expressed in fetal liver, low in bone marrow, and barely detectable in peripheral blood. Isoform 2 is expressed on hematopoietic stem cells and in epidermal basal cells (at protein level). Expressed in adult retina by rod and cone photoreceptor cells (at protein level).

亚细胞定位

Apical cell membrane