PROKR1 Q8TCW9

动力蛋白受体 1 (PK-R1) (G蛋白偶联受体 73) (G蛋白偶联受体 ZAQ) (GPR73a)

功能描述

prokineticin 1的受体。特异性偶联异源三聚体G蛋白的G(q)亚类。激活导致钙动员、磷酸肌醇周转增强以及p44/p42丝裂原活化蛋白激酶激活。可能在妊娠早期发挥作用。 {ECO:0000269|PubMed:18339712}。

组织特异性

Localizes to glandular epithelium, stroma and vascular endothelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the stomach, throughout the small intestine, colon, rectum, thyroid gland, pituitary gland, salivary gland, adrenal gland, testis, ovary, brain, spleen, prostate and pancreas.

亚细胞定位

Cell membrane; Multi-pass membrane protein.