PRG2 P13727

骨髓蛋白聚糖 (BMPG) (蛋白聚糖 2) [裂解为：嗜酸性粒细胞颗粒主要碱性蛋白 (EMBP) (MBP) (妊娠相关主要碱性蛋白)]

功能描述

细胞毒素和蠕虫毒素。也能诱导人类嗜碱性粒细胞非细胞溶解性组胺释放。参与抗寄生虫防御机制和免疫超敏反应。前体形式作为蛋白酶抑制剂，降低PAPPA的活性。{ECO:0000269|PubMed:10913121}。

组织特异性

Detected in plasma and urine (at protein level) (PubMed:25326458, PubMed:36213313, PubMed:37453717). Detected in placenta (at protein level) (PubMed:32337544). High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon.

亚细胞定位

[Bone marrow proteoglycan]: Secreted