PREX1 Q8TCU6

磷脂酰肌醇3,4,5-三磷酸依赖性Rac交换因子1蛋白 (P-Rex1) (PtdIns(3,4,5)-依赖性Rac交换因子1)

蛋白质信息 (UniProt)

磷脂酰肌醇3,4,5-三磷酸依赖性Rac交换因子1蛋白 (P-Rex1) (PtdIns(3,4,5)-依赖性Rac交换因子1)

Q8TCU6

功能描述

作为RAC鸟嘌呤核苷酸交换因子(GEF)发挥作用，通过将结合的GDP交换为游离的GTP来激活Rac蛋白。其活性被磷脂酰肌醇3,4,5-三磷酸和异三聚体G蛋白的beta gamma亚基协同激活。可能在中性粒细胞中作用于异三聚体G蛋白的下游。

组织特异性

Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues.

亚细胞定位

Cytoplasm, cytosol. Cell membrane. Note=Mainly cytosolic. Some amount is apparently associated to the plasma membrane.

关键词

3D-structure Alternative splicing Cell membrane Cytoplasm Direct protein sequencing Guanine-nucleotide releasing factor Membrane Phosphoprotein Proteomics identification Reference proteome

外部链接

UniProt: Q8TCU6

NCBI Gene

GeneCards