PRAF2 O60831

PRA1家族蛋白2

功能描述

可能参与ER/高尔基体运输及囊泡运输。在浅蓝菌素诱导的神经母细胞瘤凋亡中发挥促凋亡作用。 {ECO:0000269|PubMed:17975142, ECO:0000269|PubMed:18395978}.

组织特异性

Strong expression in the brain, small intestine, lung, spleen, and pancreas as well as in tumor tissues of the breast, colon, lung and ovary, with a weaker expression in normal tissues of the same patient. High expression in neuroblastic tumors. Strongly expressed in Purkinje cells and more moderately in cells of the molecular and the granular layers in the cerebellum. Detected in neuronal cells, but not in non-neuronal cells in the cerebral cortex, hippocampus, and lateral ventricles.

亚细胞定位

Endosome membrane