蛋白磷酸酶1核抑制因子 (NIPP-1) (蛋白磷酸酶1调节抑制亚基8) [包含：RNA衰变激活因子 (EC 3.1.4.-) (ARD-1)]
蛋白磷酸酶1核抑制因子 (NIPP-1) (蛋白磷酸酶1调节抑制亚基8) [包含：RNA衰变激活因子 (EC 3.1.4.-) (ARD-1)]
Q12972功能描述
主要核蛋白磷酸酶-1 (PP-1) 的抑制亚基。具有RNA结合活性但不切割RNA，可能将PP-1靶向RNA相关底物。可能也参与前体mRNA剪接。结合DNA并可能作为转录抑制因子。似乎为细胞增殖所必需。; FUNCTION: Isoform Gamma是一种位点特异性的单链核糖核酸内切酶，在A+U富集区切割嘌呤和嘧啶3'端的单链RNA。它在切割位点产生5'-磷酸末端。该亚型不抑制PP-1。可能参与mRNA剪接。
组织特异性
Ubiquitously expressed, with highest levels in heart and skeletal muscle, followed by brain, placenta, lung, liver and pancreas. Less abundant in kidney. The concentration and ratio between isoforms is cell-type dependent. Isoform Alpha (>90%) and isoform Beta were found in brain, heart and kidney. Isoform Gamma is mainly found in B-cells and T-lymphocytes, and has been found in 293 embryonic kidney cells.
亚细胞定位
Nucleus. Nucleus speckle. Note=Primarily, but not exclusively, nuclear.; SUBCELLULAR LOCATION: [Isoform Gamma]: Cytoplasm. Note=Found mainly in the cytoplasm.
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