蛋白质-丝氨酸O-棕榈油酰转移酶豪猪蛋白 (EC 2.3.1.250) (蛋白 MG61)
蛋白质-丝氨酸O-棕榈油酰转移酶豪猪蛋白 (EC 2.3.1.250) (蛋白 MG61)
Q9H237功能描述
蛋白质-丝氨酸O-棕榈油酰转移酶，通过介导棕榈油酸（一种16碳单不饱和脂肪酸 (C16:1(9Z))）与Wnt蛋白的结合，作为Wnt信号通路的关键调节因子。WNT蛋白的丝氨酸棕榈油酰化是其有效结合卷曲受体所必需的。 {ECO:0000250|UniProtKB:Q9JJJ7, ECO:0000269|PubMed:12034504, ECO:0000269|PubMed:20826466, ECO:0000269|PubMed:24292069}。
组织特异性
Isoform 1 is expressed in fetal brain, brain, amygdala, caudate nucleus, cerebellum, hippocampus, pituitary, thalamus, heart, skeletal muscle and testis. Isoform 4 is expressed in amygdala, corpus callosum, hippocampus, spinal cord, kidney, liver, lung, spleen, uterus, testis. Isoform 2 and isoform 3 are expressed in substantia negra, spinal cord, heart and lung.
亚细胞定位
Endoplasmic reticulum membrane
关键词