DNA定向RNA聚合酶II亚基GRINL1A (DNA-directed RNA polymerase II subunit M) (谷氨酸受体样蛋白1A)
DNA定向RNA聚合酶II亚基GRINL1A (DNA-directed RNA polymerase II subunit M) (谷氨酸受体样蛋白1A)
P0CAP2功能描述
[Isoform 1]: Appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. May play a role in the Mediator complex-dependent regulation of transcription activation. Acts as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II. {ECO:0000269|PubMed:16769904, ECO:0000269|PubMed:30190596}.
组织特异性
Detected in adult an fetal brain. Detected in heart, kidney, skeletal muscle, small intestine, lung, prostate and testis.
亚细胞定位
[Isoform 1]: Nucleus
关键词