PLXNB3 Q9ULL4

神经丛蛋白-B3

功能描述

SEMA5A的受体，在轴突导向、侵袭性生长和细胞迁移中发挥作用。刺激神经突生长并介导Ca(2+)/Mg(2+)依赖的细胞聚集。在胶质瘤细胞中，SEMA5A刺激PLXNB3导致F-actin应力纤维解聚、粘着斑破坏和细胞塌陷，并通过ARHGDIA介导的RAC1失活抑制细胞迁移和侵袭。 {ECO:0000269|PubMed:15218527, ECO:0000269|PubMed:20696765, ECO:0000269|PubMed:21706053}.

组织特异性

Expression detected in Purkinje and granular cells in cerebellum, and in brain neocortex but not in corpus callosum. Expressed in glioma cells and embryonic kidney cells (at protein level). Expressed in brain, liver, pancreas and placenta, with weak expression detected also in lung and kidney. Expressed in several glioma cell lines.

亚细胞定位

Cell membrane