PLXDC1 Q8IUK5

含Plexin域蛋白1 (肿瘤内皮标志物3) (肿瘤内皮标志物7)

功能描述

在内皮细胞毛细血管形态发生中起关键作用。 {ECO:0000250}。

组织特异性

Detected in urine (at protein level) (PubMed:25326458, PubMed:36213313, PubMed:37453717). Detected in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. Not detectable in endothelial cells from normal tissue. Expressed in fibrovascular membrane with increased expression in individuals with proliferative diabetic retinopathy.

亚细胞定位

Secreted