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PLOD2 O00469

前胶原-赖氨酸,2-氧戊二酸5-双加氧酶2 (EC 1.14.11.4) (赖氨酰羟化酶2) (LH2)

蛋白质信息 (UniProt)

前胶原-赖氨酸,2-氧戊二酸5-双加氧酶2 (EC 1.14.11.4) (赖氨酰羟化酶2) (LH2)

O00469

功能描述

在胶原蛋白的-Xaa-Lys-Gly-序列中形成羟赖氨酸残基。这些羟赖氨酸作为碳水化合物单位的附着位点,对于分子间胶原蛋白交联的稳定性至关重要。 {ECO:0000250|UniProtKB:P24802}。

组织特异性

Highly expressed in pancreas and muscle. Isoform 1 and isoform 2 are expressed in the majority of the examined cell types. Isoform 2 is specifically expressed in skin, lung, dura and aorta.

亚细胞定位

Rough endoplasmic reticulum membrane

关键词

Alternative splicing Cytoplasm Dioxygenase Disease variant Endoplasmic reticulum Glycoprotein Iron Membrane Metal-binding Osteogenesis imperfecta