PLEKHG5 O94827

含Pleckstrin同源结构域家族G成员5 (含PH结构域家族G成员5) (鸟苷酸交换因子720) (GEF720)

功能描述

作为RAB26的鸟嘌呤交换因子(GEF)发挥作用，从而调节运动神经元轴突末梢突触小泡的自噬(By similarity)。参与神经元细胞分化的控制(PubMed:11704860)。通过调节内皮细胞趋化性在血管生成中发挥作用。也影响巨噬细胞和破骨细胞的迁移、粘附以及基质/骨降解(PubMed:23777631)。 {ECO:0000250|UniProtKB:Q66T02, ECO:0000269|PubMed:11704860, ECO:0000269|PubMed:23777631}.

组织特异性

Predominantly expressed in the peripheral nervous system and brain. Highest expression is observed in heart, lung, kidney, testis and moderate expression is present in spleen, pancreas, skeletal muscle, ovary and liver. Weakly expressed in glioblastoma (GBM) cell lines.

亚细胞定位

Cytoplasm