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PLEKHA1 Q9HB21

含Pleckstrin同源结构域家族A成员1 (PH结构域家族A成员1) (串联PH结构域蛋白1) (TAPP-1)

蛋白质信息 (UniProt)

含Pleckstrin同源结构域家族A成员1 (PH结构域家族A成员1) (串联PH结构域蛋白1) (TAPP-1)

Q9HB21

功能描述

特异性结合磷脂酰肌醇3,4-二磷酸 (PtdIns3,4P2),但不结合其他磷酸肌醇。可能招募其他蛋白质至质膜。 {ECO:0000269|PubMed:11001876, ECO:0000269|PubMed:11513726, ECO:0000269|PubMed:14516276}.

组织特异性

Highly expressed in skeletal muscle, thymus, pancreas, placenta and lung. Detected at low levels in brain, heart, peripheral blood leukocytes, testis, ovary, spinal cord, thyroid, kidney, liver, small intestine and colon.

亚细胞定位

Cytoplasm

关键词

3D-structure Alternative splicing Cell membrane Cytoplasm Lipid-binding Membrane Nucleus Phosphoprotein Proteomics identification Reference proteome