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PLCH1 Q4KWH8

1-磷脂酰肌醇4,5-二磷酸磷酸二酯酶eta-1 (EC 3.1.4.11) (磷酸肌醇磷脂酶C-eta-1) (磷脂酶C-eta-1) (PLC-eta-1) (磷脂酶C样蛋白3) (PLC-L3)

蛋白质信息 (UniProt)

1-磷脂酰肌醇4,5-二磷酸磷酸二酯酶eta-1 (EC 3.1.4.11) (磷酸肌醇磷脂酶C-eta-1) (磷脂酶C-eta-1) (PLC-eta-1) (磷脂酶C样蛋白3) (PLC-L3)

Q4KWH8

功能描述

第二信使分子二酰甘油(DAG)和1,4,5-三磷酸肌醇(IP3)的产生是由钙激活的磷脂酰肌醇特异性磷脂酶C酶介导的。 {ECO:0000269|PubMed:15702972}。

组织特异性

Expressed in brain and to a lower extent in lung. In brain, it is found in cerebrum, cerebellum and spinal cord. In embryo expressed in the notochord, developing spinal cord (in a ventral to dorsal gradient), dorsal root ganglia, cerebellum and dermatomyosome.

亚细胞定位

Cytoplasm

关键词

Alternative splicing Calcium Cytoplasm Disease variant Holoprosencephaly Hydrolase Lipid degradation Lipid metabolism Membrane Metal-binding