PILRA Q9UKJ1

配对免疫球蛋白样2型受体α (细胞表面受体FDF03) (抑制性受体PILR-α)

功能描述

成对受体由高度相关的激活性和抑制性受体组成，广泛参与免疫系统的调节。PILRA被认为通过其SH2结构域招募细胞质磷酸酶如PTPN6/SHP-1和PTPN11/SHP-2，通过对信号分子的去磷酸化阻断信号转导，从而作为细胞信号传导抑制受体发挥作用。PIANP的受体。 {ECO:0000269|PubMed:10903717, ECO:0000269|PubMed:21241660}.; FUNCTION: (微生物感染) 作为单纯疱疹病毒1型的进入共受体。 {ECO:0000269|PubMed:18358807}.

组织特异性

Predominantly detected in hemopoietic tissues and is expressed by monocytes, macrophages, and granulocytes, but not by lymphocytes. Also strongly expressed by dendritic cells (DC); preferentially by CD14+/CD1a- DC derived from CD34+ progenitors. Also expressed by CD11c+ blood and tonsil DC, but not by CD11c- DC precursors.

亚细胞定位

[Isoform 1]: Cell membrane