PIH1D1 Q9NWS0

含PIH1结构域蛋白1 (核仁蛋白17同源物)

功能描述

参与C/D box小核仁核糖核蛋白(snoRNP)颗粒的组装 (PubMed:17636026)。募集SWI/SNF复合物至rRNA基因的核心启动子并增强pre-rRNA转录 (PubMed:22368283, PubMed:24036451)。介导TELO2与R2TP复合物的相互作用，这对MTOR和SMG1的稳定性是必需的 (PubMed:20864032)。正调控mTORC1复合物的组装和活性 (PubMed:24036451)。 {ECO:0000269|PubMed:17636026, ECO:0000269|PubMed:20864032, ECO:0000269|PubMed:22368283, ECO:0000269|PubMed:24036451}。

组织特异性

Expressed at low levels in normal mammary epithelial cells (at protein level) (PubMed:24036451). Highest expression in lung, leukocyte and placenta. Expressed at lower levels in brain, prostate, colon, heart, small intestine, liver, ovary, pancreas, skeletal muscle, spleen, testis and thymus (PubMed:21078300).

亚细胞定位

Nucleus