孕酮诱导阻断因子1 (PIBF) (90 kDa中心体蛋白) (CEP90)
孕酮诱导阻断因子1 (PIBF) (90 kDa中心体蛋白) (CEP90)
Q8WXW3功能描述
在纤毛发生中起作用。 {ECO:0000269|PubMed:26167768}.; FUNCTION: [Isoform 1]: 一种中心体周围蛋白，是维持有丝分裂纺锤体极完整性所必需的 (PubMed:21224392)。是PCM1在中心体积聚以及BBS4等中心体卫星蛋白募集所必需的。通过与PCM1结合，可能参与初级纤毛的形成 (PubMed:23110211)。是CEP63中心体定位及其与WDR62相互作用所必需的。与CEP63共同促进中心体复制。促进CDK2的中心体定位 (PubMed:26297806)。 {ECO:0000269|PubMed:21224392, ECO:0000269|PubMed:23110211, ECO:0000269|PubMed:26297806}.; FUNCTION: [Isoform 4]: 分泌形式是孕酮的介质，通过作用于磷脂酶A2酶干扰花生四烯酸代谢，诱导偏向Th2型的免疫反应，并通过控制蜕膜自然杀伤细胞(NK)的活性发挥抗流产作用 (PubMed:12516630, PubMed:14634107, PubMed:3863495)。通过JAK/STAT通路信号传导增加Th2型细胞因子的产生。激活STAT6并抑制STAT4磷酸化。通过一种未鉴定的受体进行的信号传导似乎涉及IL4R和一种GPI锚定蛋白 (PubMed:16393965, PubMed:25218441)。 {ECO:0000269|PubMed:12516630, ECO:0000269|PubMed:14634107, ECO:0000269|PubMed:16393965, ECO:0000269|PubMed:25218441, ECO:0000269|PubMed:3863495, ECO:0000305|PubMed:11407300}.
组织特异性
Expressed at highest levels in testis. Moderate expression is detected in spleen, thymus, prostate, ovary, small intestine, and colon (PubMed:11935316). Expressed in the first trimester pregnancy decidua (PubMed:12516630). Localized to extravillous cytotrophoblast (at protein level). Also found in syncytiotrophoblast and part of the villous cytotrophoblast. Isoform 1 is expressed in first trimester and term villous trophoblast; trophoblast cells can additionally express other isoforms (PubMed:18817979). Overexpressed in solid tumors from stomach and uterus and in cells from ovary, cervical, breast, lymphoma and leukemia cancer (PubMed:25218441).
亚细胞定位
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
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