磷脂酰肌醇4-激酶β (PI4K-beta) (PI4Kbeta) (PtdIns 4-激酶β) (EC 2.7.1.67) (NPIK) (PI4K92) (PI4KIII)
磷脂酰肌醇4-激酶β (PI4K-beta) (PI4Kbeta) (PtdIns 4-激酶β) (EC 2.7.1.67) (NPIK) (PI4K92) (PI4KIII)
Q9UBF8功能描述
在生成第二信使肌醇-1,4,5-三磷酸(PIP)的第一步限速步骤中磷酸化磷脂酰肌醇(PI)。可能通过其磷酸化作用调节有丝分裂期间的高尔基体解体/重组。参与高尔基体到质膜的运输 (By similarity) (PubMed:10559940, PubMed:11277933, PubMed:12749687, PubMed:9405935)。可能在内耳发育中起重要作用。 {ECO:0000250|UniProtKB:O08561, ECO:0000269|PubMed:10559940, ECO:0000269|PubMed:11277933, ECO:0000269|PubMed:12749687, ECO:0000269|PubMed:33358777, ECO:0000269|PubMed:9405935}.; FUNCTION: (Microbial infection) 在爱知病毒RNA复制中起重要作用 (PubMed:22124328, PubMed:22258260, PubMed:27989622)。被ACBD3募集至病毒复制位点 (PubMed:22124328, PubMed:27989622)。 {ECO:0000269|PubMed:22124328, ECO:0000269|PubMed:22258260, ECO:0000269|PubMed:27989622}.; FUNCTION: (Microbial infection) 人冠状病毒SARS-CoV细胞刺突介导的进入所必需。 {ECO:0000269|PubMed:22253445}.
组织特异性
Widely expressed with highest levels in heart, skeletal muscle, pancreas, testis and ovary. Weakly expressed in liver (PubMed:9020160, PubMed:9405935, PubMed:9405938). Expressed in the innear ear in the epithelium of the spinal organ of corti.
亚细胞定位
Endomembrane system. Mitochondrion outer membrane; Peripheral membrane protein. Rough endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus
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