PI4KA P42356

磷脂酰肌醇4-激酶α (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) (磷脂酰肌醇4-激酶III alpha)

蛋白质信息 (UniProt)

磷脂酰肌醇4-激酶α (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) (磷脂酰肌醇4-激酶III alpha)

P42356

功能描述

作用于磷脂酰肌醇 (PtdIns)，这是生成第二信使肌醇-1,4,5-三磷酸过程中第一步关键步骤。 {ECO:0000269|PubMed:10101268, ECO:0000269|PubMed:23229899}.

组织特异性

Expressed ubiquitously. Highest levels in placenta and brain. Little or no expression in lung, liver, pancreas, testis or leukocytes.

亚细胞定位

Cytoplasm

关键词

3D-structure Alternative splicing ATP-binding Cell membrane Cytoplasm Disease variant Hereditary spastic paraplegia Kinase Lipid metabolism Membrane

UniProt: P42356

NCBI Gene

GeneCards