PHF1 O43189

PHD指蛋白1 (蛋白PHF1) (hPHF1) (类Polycomb蛋白1) (hPCl1)

功能描述

Polycomb group (PcG)蛋白，特异性结合‘Lys-36’位三甲基化的组蛋白H3 (H3K36me3)并招募PRC2复合物。参与DNA损伤反应并被招募至双链断裂(DSBs)处。通过结合H3K36me3（一种转录激活标记）并招募PRC2复合物发挥作用：然而，将PRC2复合物招募至H3K36me3是增强还是抑制PRC2复合物介导的H3K27me3甲基化尚不清楚。根据一些报道，PHF1招募PRC2通过诱导PRC2和H3K27me3扩散至H3K36me3位点来促进H3K27me3及随后的基因沉默 (PubMed:18285464, PubMed:23273982)。根据另一篇报道，PHF1在双链断裂(DSBs)处招募PRC2复合物并抑制PRC2的活性 (PubMed:23142980)。调节p53/TP53稳定性并延长其周转：可能通过特异性结合甲基化形式的p53/TP53发挥作用。 {ECO:0000269|PubMed:18086877, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:18385154, ECO:0000269|PubMed:23142980, ECO:0000269|PubMed:23150668, ECO:0000269|PubMed:23273982}。

组织特异性

Highest levels in heart, skeletal muscle, and pancreas, lower levels in brain, placenta, lung, liver and kidney.

亚细胞定位

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes specifically to the promoters of numerous target genes. Localizes to double-strand breaks (DSBs) sites following DNA damage. Co-localizes with NEK6 in the centrosome.