PGRMC1 O00264

膜相关孕酮受体组分1 (mPR) (Dap1) (IZA)

蛋白质信息 (UniProt)

膜相关孕酮受体组分1 (mPR) (Dap1) (IZA)

O00264

功能描述

孕酮结合蛋白复合物的组分 (PubMed:28396637)。结合孕酮 (PubMed:25675345)。具有许多报道的细胞功能（血红素稳态，与CYPs相互作用）。维持子宫组织结构和正常雌性生殖寿命所必需 (By similarity)。细胞内血红素伴侣。通过与FECH相互作用调节血红素合成，并作为至少部分血红素蛋白的血红素供体 (PubMed:27599036)。与TMEM97受体和低密度脂蛋白受体/LDLR形成三元复合物，从而增加LDLR介导的LDL脂蛋白内化 (PubMed:30443021)。 {ECO:0000250|UniProtKB:O55022, ECO:0000269|PubMed:25675345, ECO:0000269|PubMed:27599036, ECO:0000269|PubMed:30443021, ECO:0000303|PubMed:28396637}。

组织特异性

Detected in urine (at protein level) (PubMed:36213313, PubMed:37453717). Expressed by endometrial glands and stroma (at protein level) (PubMed:23793472). Widely expressed, with highest expression in liver and kidney.

亚细胞定位

Microsome membrane

关键词

3D-structure Alternative splicing Direct protein sequencing Endoplasmic reticulum Glycoprotein Iron Lipid-binding Membrane Metal-binding Microsome

外部链接

UniProt: O00264

NCBI Gene

GeneCards