孕酮受体 (PR) (核受体亚家族3组成员3)
孕酮受体 (PR) (核受体亚家族3组成员3)
P06401功能描述
类固醇激素及其受体参与真核基因表达的调节，并影响靶组织中的细胞增殖和分化。根据isoform的不同，progesterone receptor作为转录激活因子或抑制因子发挥作用。 {ECO:0000269|PubMed:10757795, ECO:0000269|PubMed:1587864, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9407067, ECO:0000305}.; FUNCTION: [Isoform A]: 类固醇激素受体转录活性的配体依赖性显性抑制因子，包括对其isoform B、MR和ER的抑制。反式抑制活性可能涉及corepressor NCOR2的募集。 {ECO:0000269|PubMed:7969170, ECO:0000269|PubMed:8180103, ECO:0000269|PubMed:8264658, ECO:0000305, ECO:0000305|PubMed:10757795}.; FUNCTION: [Isoform B]: 多种细胞类型中若干progesterone依赖性启动子的转录激活因子。参与激素刺激时SRC依赖性MAPK信号通路的激活。 {ECO:0000269|PubMed:7969170}.; FUNCTION: [Isoform 4]: 在progesterone刺激下增加线粒体膜电位和细胞呼吸。
组织特异性
In reproductive tissues the expression of isoform A and isoform B varies as a consequence of developmental and hormonal status. Isoform A and isoform B are expressed in comparable levels in uterine glandular epithelium during the proliferative phase of the menstrual cycle. Expression of isoform B but not of isoform A persists in the glands during mid-secretory phase. In the stroma, isoform A is the predominant form throughout the cycle. Heterogeneous isoform expression between the glands of the endometrium basalis and functionalis is implying region-specific responses to hormonal stimuli.
亚细胞定位
Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both hormone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases.; SUBCELLULAR LOCATION: [Isoform A]: Nucleus. Cytoplasm. Note=Mainly nuclear.; SUBCELLULAR LOCATION: [Isoform 4]: Mitochondrion outer membrane
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