PGLYRP3 Q96LB9

肽聚糖识别蛋白3 (肽聚糖识别蛋白I-alpha) (PGLYRPIalpha) (PGRP-I-alpha) (肽聚糖识别蛋白中间体alpha)

功能描述

模式受体，结合革兰氏阳性菌的胞壁肽聚糖(PGN)。对革兰氏阳性菌具有杀菌活性。可能通过干扰肽聚糖生物合成杀死革兰氏阳性菌。也结合革兰氏阴性菌，并对革兰氏阴性菌具有抑菌活性。在先天免疫中发挥作用。 {ECO:0000269|PubMed:16354652}。

组织特异性

Detected in skin epidermis, eccrine sweat glands and ducts, ciliary body epithelial cells of the eye, in small intestine, colon, stomach and in mature epithelial cells of the tongue (at protein level). Highly expressed in skin and esophagus, expressed also in tonsils and thymus and to a much lesser extent in the stomach, descending colon, rectum and brain.

亚细胞定位

Secreted