胎盘生长因子 (PlGF)
胎盘生长因子 (PlGF)
P49763功能描述
在血管生成和内皮细胞生长中具有活性的生长因子，刺激其增殖和迁移。它结合受体FLT1/VEGFR-1。Isoform PlGF-2以肝素依赖的方式结合NRP1/neuropilin-1和NRP2/neuropilin-2。亦促进肿瘤细胞生长。 {ECO:0000269|PubMed:21215706}。
组织特异性
While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas.
亚细胞定位
Secreted. Note=The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.
关键词