PEG10 Q86TG7

逆转录转座子衍生蛋白 PEG10 (胚胎癌分化调节蛋白) (哺乳动物逆转录转座子衍生蛋白 2) (髓鞘表达因子 3 样蛋白 1) (MEF3 样蛋白 1) (父系表达基因 10 蛋白) (含逆转录转座子 gag 结构域蛋白 3) (逆转录转座子衍生 gag 样多聚蛋白) (Ty3/Gypsy 样蛋白)

功能描述

逆转录转座子来源的蛋白质，结合自身的mRNA并自组装成病毒样衣壳 (PubMed:34413232)。形成病毒样细胞外囊泡，包裹自身的mRNA并从细胞中释放，促进PEG10 mRNA的细胞间转移 (PubMed:34413232)。在5'-UTR区域、靠近核衣壳(NC)和蛋白酶(PRO)编码序列边界附近的区域以及3'-UTR区域起始处结合自身的mRNA (PubMed:34413232)。参与胎盘形成：滋养层干细胞分化所必需 (By similarity)。参与脂肪细胞分化的即刻早期阶段 (By similarity)。在多种癌症中过表达并促进肿瘤进展：通过驱动细胞周期从G0/G1期进程来促进细胞增殖 (PubMed:12810624, PubMed:16423995, PubMed:26235627, PubMed:28193232)。通过抑制TGF-beta信号传导促进癌症进展，可能通过与TGF-beta受体ACVRL1相互作用实现 (PubMed:15611116, PubMed:26235627, PubMed:30094509)。可能结合髓鞘碱性蛋白(MBP)启动子中MB1结构域的5'-GCCTGTCTTT-3' DNA序列；然而需要更多证据来确认该结果 (By similarity)。 {ECO:0000250|UniProtKB:Q7TN75, ECO:0000269|PubMed:12810624, ECO:0000269|PubMed:15611116, ECO:0000269|PubMed:16423995, ECO:0000269|PubMed:26235627, ECO:0000269|PubMed:28193232, ECO:0000269|PubMed:30094509, ECO:0000269|PubMed:34413232}。

组织特异性

Expressed in the cytotrophoblast layer but not in the overlying syncytiotrophoblast of the placenta. Expressed in prostate and breast carcinomas but not in normal breast and prostate epithelial cells. Expressed in the Hep-G2 cell line (at protein level). Expressed in brain, liver, spleen, kidney, thymus, lung, ovary, testis, reactive lymph node, skeletal muscle, adipose tissue and placenta. Expressed in pancreatic and hepatocellular carcinomas (HCC).

亚细胞定位

Extracellular vesicle membrane