PEAR1 Q5VY43

血小板内皮聚集受体1 (hPEAR1) (多表皮生长因子样结构域蛋白12) (多EGF样结构域蛋白12)

功能描述

通过与SVEP1相互作用及随后的AKT/mTOR信号激活，为SVEP1介导的血小板激活所必需 (PubMed:36792666)。可能参与造血作用的早期阶段 (By similarity)。 {ECO:0000250|UniProtKB:Q8VIK5, ECO:0000269|PubMed:36792666}。

组织特异性

Expressed in umbilical vein endothelial cells and platelets (at protein level) (PubMed:15851471, PubMed:36792666). Expressed in coronary artery smooth muscle cells (at protein level) (PubMed:36792666). Expressed in heart, kidney, skeletal muscle, pancreas, ovary, breast, lung, brain cortex, hypothalamus, spinal cord, dorsal root ganglion (PubMed:15851471). Expressed in umbilical artery endothelial cells, megakaryocytes, osteoblasts, coronary muscle and erythroid cells (PubMed:15851471).

亚细胞定位

Cell membrane