星形胶质细胞磷蛋白 PEA-15 (星形胶质细胞中富集的15 kDa磷蛋白) (糖尿病中富集的磷蛋白) (PED)
星形胶质细胞磷蛋白 PEA-15 (星形胶质细胞中富集的15 kDa磷蛋白) (糖尿病中富集的磷蛋白) (PED)
Q15121功能描述
阻断Ras介导的整合素活化抑制，并调节ERK MAP激酶级联反应。通过将RPS6KA3滞留在细胞质中抑制其活性 (By similarity)。抑制TNFRSF6和TNFRSF1A介导的CASP8活性和细胞凋亡。通过控制质膜上SLC2A1葡萄糖转运蛋白的含量以及SLC2A4从细胞内部到表面的胰岛素依赖性转运来调节葡萄糖转运。 {ECO:0000250, ECO:0000269|PubMed:10442631, ECO:0000269|PubMed:9670003}.
组织特异性
Ubiquitously expressed. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose-producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls.
亚细胞定位
Cytoplasm. Note=Associated with microtubules.
关键词