PDLIM1 O00151

PDZ和LIM结构域蛋白1 (C端LIM结构域蛋白1) (Elfin) (LIM结构域蛋白CLP-36)

功能描述

细胞骨架蛋白，可能作为适配蛋白将其他蛋白（如激酶）带到细胞骨架上 (PubMed:10861853)。参与成纤维细胞中应力纤维的组装、解聚和定向。ACTN1和PALLD在应力纤维上的定位所必需的。成纤维细胞的细胞迁移和维持细胞极性所必需的 (By similarity)。 {ECO:0000250|UniProtKB:P52944, ECO:0000269|PubMed:10861853}。

组织特异性

Strongly expressed in the heart and skeletal muscle, moderately expressed in the spleen, small intestine, colon, placenta, and lung. A lower level expression is seen in liver, thymus, kidney, prostate and pancreas and is not found in the brain, testis, ovary, and peripheral blood leukocytes.

亚细胞定位

Cytoplasm