PDGFD Q9GZP0

血小板源性生长因子D (PDGF-D) (虹膜表达生长因子) (脊髓源性生长因子B) (SCDGF-B) [裂解为：血小板源性生长因子D，潜伏形式 (PDGFD潜伏形式)；血小板源性生长因子D，受体结合形式 (PDGFD受体结合形式)]

功能描述

生长因子，在胚胎发育、细胞增殖、细胞迁移、存活和趋化的调节中起重要作用。间充质来源细胞的强效有丝分裂原。在伤口愈合中起重要作用。在血管生成过程中诱导巨噬细胞募集、增加组织间隙压力和血管成熟。可引发导致系膜增生性肾小球肾炎的事件，包括单核细胞和巨噬细胞的流入以及细胞外基质的产生（通过相似性）。{ECO:0000250, ECO:0000269|PubMed:11331881, ECO:0000269|PubMed:15271796}。

组织特异性

Expressed at high levels in the heart, pancreas, adrenal gland and ovary and at low levels in placenta, liver, kidney, prostate, testis, small intestine, spleen and colon. In the kidney, expressed by the visceral epithelial cells of the glomeruli. A widespread expression is also seen in the medial smooth muscle cells of arteries and arterioles, as well as in smooth muscle cells of vasa rectae in the medullary area. Expressed in the adventitial connective tissue surrounding the suprarenal artery. In chronic obstructive nephropathy, a persistent expression is seen in glomerular visceral epithelial cells and vascular smooth muscle cells, as well as de novo expression by periglomerular interstitial cells and by some neointimal cells of atherosclerotic vessels. Expression in normal prostate is seen preferentially in the mesenchyme of the gland while expression is increased and more profuse in prostate carcinoma. Expressed in many ovarian, lung, renal and brain cancer-derived cell lines.

亚细胞定位

Secreted