血小板衍生生长因子C (PDGF-C) (Fallotein) (脊髓衍生生长因子) (SCDGF) (VEGF-E) [裂解为：血小板衍生生长因子C，潜伏形式 (PDGFC潜伏形式)；血小板衍生生长因子C，受体结合形式 (PDGFC受体结合形式)]
血小板衍生生长因子C (PDGF-C) (Fallotein) (脊髓衍生生长因子) (SCDGF) (VEGF-E) [裂解为：血小板衍生生长因子C，潜伏形式 (PDGFC潜伏形式)；血小板衍生生长因子C，受体结合形式 (PDGFC受体结合形式)]
Q9NRA1功能描述
生长因子，在胚胎发育、细胞增殖、细胞迁移、存活和趋化的调节中起重要作用。是间充质来源细胞的有效有丝分裂原和趋化因子。胚胎发育期间正常骨骼形成所必需的，特别是颅面骨骼的正常发育和腭的正常发育。胚胎发育期间正常皮肤形态发生所必需的。在伤口愈合中起重要作用，似乎参与三个阶段：炎症、增殖和重塑。在血管生成和血管发育中起重要作用。参与纤维化过程，即间质成纤维细胞转化为肌成纤维细胞并发生胶原沉积。CUB结构域在冠状动脉平滑肌细胞中具有促有丝分裂活性，提示其作用超出了维持PDGF结构域潜伏状态的范围。在细胞核中，PDGFC似乎具有额外的功能。 {ECO:0000269|PubMed:10806482, ECO:0000269|PubMed:10858496, ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:11854040, ECO:0000269|PubMed:12032822, ECO:0000269|PubMed:15061151, ECO:0000269|PubMed:15372073, ECO:0000269|PubMed:15389578, ECO:0000269|PubMed:15728360, ECO:0000269|PubMed:15911618, ECO:0000269|PubMed:16439802, ECO:0000269|PubMed:18055825}。
组织特异性
Expressed in the fallopian tube, vascular smooth muscle cells in kidney, breast and colon and in visceral smooth muscle of the gastrointestinal tract. Highly expressed in retinal pigment epithelia. Expressed in medulloblastoma. In the kidney, constitutively expressed in parietal epithelial cells of Bowman's capsule, tubular epithelial cells and in arterial endothelial cells (at protein level). Highly expressed in the platelets, prostate, testis and uterus. Higher expression is observed in uterine leiomyomata. Weaker expression in the spleen, thymus, heart, pancreas, liver, ovary cells and small intestine, and negligible expression in the colon and peripheral blood leukocytes.
亚细胞定位
Cytoplasm, cytosol
关键词