血小板源性生长因子亚基B (PDGF subunit B) (PDGF-2) (血小板源性生长因子B链) (血小板源性生长因子β多肽) (原癌基因c-Sis) (贝卡普勒明)
血小板源性生长因子亚基B (PDGF subunit B) (PDGF-2) (血小板源性生长因子B链) (血小板源性生长因子β多肽) (原癌基因c-Sis) (贝卡普勒明)
P01127功能描述
生长因子，在胚胎发育、细胞增殖、细胞迁移、存活和趋化的调节中起重要作用。是间充质来源细胞的强效有丝分裂原 (PubMed:26599395)。为中枢神经系统、皮肤、肺、心脏和胎盘中周细胞和血管平滑肌细胞的正常增殖和募集所必需。为正常血管发育和肾小球正常发育所必需。在伤口愈合中起重要作用。信号传导通过与PDGFA形成异源二聚体进行调节 (By similarity)。 {ECO:0000250|UniProtKB:P31240, ECO:0000269|PubMed:26599395}。
组织特异性
Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung.
亚细胞定位
Secreted. Note=Released by platelets upon wounding.
关键词