PDE5A O76074

cGMP特异性3',5'-环磷酸二酯酶 (EC 3.1.4.35) (cGMP结合cGMP特异性磷酸二酯酶) (CGB-PDE)

蛋白质信息 (UniProt)

cGMP特异性3',5'-环磷酸二酯酶 (EC 3.1.4.35) (cGMP结合cGMP特异性磷酸二酯酶) (CGB-PDE)

O76074

功能描述

通过调节细胞内环核苷酸浓度在信号转导中发挥作用。该磷酸二酯酶催化cGMP特异性水解为5'-GMP (PubMed:15489334, PubMed:9714779)。特异性调节一氧化氮生成的cGMP (PubMed:15489334)。 {ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:9714779}。

组织特异性

Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung.

关键词

3D-structure Allosteric enzyme Alternative splicing cGMP cGMP-binding Hydrolase Metal-binding Nucleotide-binding Phosphoprotein Proteomics identification

外部链接

UniProt: O76074

NCBI Gene

GeneCards