PDCL3 Q9H2J4

类感光蛋白3 (HTPHLP) (PhPL3) (病毒IAP相关因子1) (VIAF-1)

蛋白质信息 (UniProt)

类感光蛋白3 (HTPHLP) (PhPL3) (病毒IAP相关因子1) (VIAF-1)

Q9H2J4

功能描述

作为血管生成VEGF受体KDR/VEGFR2的chaperone，通过抑制其泛素化和降解来增加其丰度 (PubMed:23792958, PubMed:26059764)。抑制含chaperonin T-complex (CCT)的折叠活性，从而导致细胞骨架肌动蛋白折叠受抑 (PubMed:17429077)。在热休克期间与HSP90和HSP40/70 chaperone复合物一起充当chaperone (By similarity)。在细胞凋亡过程中调节caspases的激活 (PubMed:15371430)。 {ECO:0000250|UniProtKB:Q4KLJ8, ECO:0000269|PubMed:15371430, ECO:0000269|PubMed:17429077, ECO:0000269|PubMed:23792958, ECO:0000269|PubMed:26059764}。

组织特异性

Expressed in endothelial cells (at protein level) (PubMed:26059764). Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine and colon (PubMed:15371430).

亚细胞定位

Cytoplasm

关键词

3D-structure Acetylation Angiogenesis Apoptosis Chaperone Cytoplasm Endoplasmic reticulum Phosphoprotein Proteomics identification Reference proteome

外部链接

UniProt: Q9H2J4

NCBI Gene

GeneCards